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KMID : 0364019960290040414
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Korean Journal of Thoracic and Cardiovascular Surgery
1996 Volume.29 No. 4 p.414 ~ p.419
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Treatment of Malignant Effusion with Intracavitary OK-432 Chemical Pleurodesis
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김맹호
이헌재/최영호/김광택/이인성/김형묵
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Abstract
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To determine the efficacy of OK-432 as pleural sclerosant, we examined the outcomes in 81 patients (age; 27 to 82 years)with malignant pleural effusion and the outcomes in 64 patients recieving OK-432 3-10KE(1 Klinische Einheit unit) through a
chest
tube for malignant pleural effusions. Of 81 patients with malignant pleural effusion, 40 patients had lung cancer. Lung cancer is the most frequent cause of malignant pleural effusion in men and women, in which 57% of it was adenocarcinoma.
Eighty
seven
percent of patient had respiratory symptom. Of the 64 patients with intracavitary injection of OK-432 for malignant pleural effusion, 59 patients had a complete short-term response(no fluid reaccumulation during l month after intracavitary
injection of
OK-432). Five patiens of the non-responders had partial control of effusion with improvement in respiratory symptoms and these patients underwent thoracentesis. Of the 51 patients who survived longer than l month, 48 patients did not have
reaccumulation
of the fluid during follow up. Fever after intracavitary injection of OK-432 was a major side effect although but that was easily controlled with non-steroidal anti-inflammatory drug therapy. Thus the efficacy of intracavitary OK-432 injection
for
malignant pleural effusion was very helpful.
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KEYWORD
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